Doctors report a significant increase in lung cancer cases among women and young people, attributing this rise to factors such as early-age smoking, exposure to carcinogens like asbestos, pollution from traffic and fossil fuel emissions, and indoor cooking gas.
In another paper from the series, researchers, including those from the All India Institute of Medical Sciences (AIIMS), New Delhi, found that air pollution can cause lung cancer even in non-smokers. They analysed the impact of climate change on lung cancer in Asia.
"These results are disappointing as it was our hope that this combination might yield improved outcomes for people living with metastatic non-squamous lung cancer," Chief Medical Officer Levi Garraway said in the statement.
According to lead author Stephen Chun, M.D., associate professor of Radiation Oncology, this study should bring finality to what has been a long-standing debate over optimal radiation technique for locally advanced NSCLC.
The FDA cited findings from an inspection of a third-party manufacturing facility in its so-called complete response letter, the companies said late on Wednesday.
The ADJUVANT BR.31 Phase III trial did not meet the primary endpoint of disease-free survival versus a placebo in early-stage non-small-cell lung cancer after tumour removal in patients whose tumours express PD-L1 on 25 per cent or more tumour cells, the drugmaker said.
Lorlatinib, which is already approved and available under the brand name Lorbrena in the United States, was tested in a clinical trial of hundreds of people with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).
Prevention is the most effective way to reduce mortality due to cancer from tobacco. However, despite increased education and awareness about the harmful effects of tobacco use, people are still prone to start smoking due to peer influence and the easy availability of tobacco products. Hence, it’s important for those who use tobacco products regularly to undergo timely screening.
An analysis showed the trial will not achieve the main goal of statistically significant improvement in recurrence-free survival as more side effects led to several patients discontinuing the combination treatment versus those on Keytruda alone, Merck said.
Due to its increased sensitivity and capacity to identify mutations with low allele frequency, next-generation sequencing (NGS) is gradually displacing conventional methods of ALK mutation detection.
Prostate cancer is the most widespread cancer amongst men, accounting for about 15 percent of cases. It mostly emerges after the age of 50 and becomes more frequent as men age.
Get updates on your preferred social platform
Follow us for the latest news, insider access to events and more.
